In the case of side-effects from the gastrointestinal system, the dose will be reduced to the dose where there were no symptoms or there were symptoms that patients accepts.

Szulinska M, Loniewski I, van Hemert S, Sobieska M, Bogdanski P. Dose-Dependent Effects of Multispecies Probiotic Supplementation on the Lipopolysaccharide (LPS) Level and Cardiometabolic Profile in Obese Postmenopausal Women: A 12-Week Randomized Clinical Trial. Nutrients. 2018 Jun 15;10(6):773. doi: 10.3390/nu10060773. Before the test, the participants were informed about the need to stay fasting 8-12 hours and a minimum of 24 hours after physical activity. Physically active people should take special care about the tightness of their intestines. First of all, they are especially prone to the dysfunctions of the intestinal barrier due to the fact that each training session is a considerable stress factor, disturbing eubiosis (bacterial balance) of the intestines. Secondly, probiotic therapy allows to avoid digestive discomfort, often experienced during training. Thirdly, the tightness of the intestinal barrier influences the functioning of brain-gut axis, which is reflected in the functionality of the nervous system, which mainly decides about our effort and motor abilities. The investigators have chosen Sanprobi Barrier multi-strain formula probiotic because it is identical, in relation to bacterial strains and number, to Ecologic® BARRIER which has been proven in in vitro studies to improve the function of epithelial barrier of the intestine.

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The investigators have chosen Sanprobi Barrier multi-strain formula probiotic because it is identical, in relation to bacterial strains and number, to Ecologic® BARRIER which has been proven in in vitro studies to improve the function of epithelial barrier of the intestine. It was also shown that 12-week administration of strains included in Ecologic® BARRIER in obese postmenopausal women improved intestinal barrier permeability marker (lipopolysaccharide) and cardiometabolic risk factors (waist, fat mass, subcutaneous fat, uric acid, total cholesterol, triglycerides, low-density lipoprotein cholesterol, glucose, insulin, and homeostatic model assessment - insulin resistance (HOMA-IR). To determine the level of cardiopulmonary efficiency using the Bruce protocol test on a medical treadmill were performed. Therefore, fecal and serum calprotectin content may be proportional to the number of neutrophils migrating through the gastric and intestinal mucosa and may be associated with inflammatory diseases of the gastrointestinal tract. kapsułka zawiera łącznie ≥2,5×10 9 CFU/g żywych szczepów bakterii Bifidobacterium lactis W52, Lactobacillus brevis W63, Lactobacillus casei W56, Lactococcus lactis W19, Lactococcus lactis W58, Lactobacillus acidophilus W37, Bifidobacterium bifidum W23, Bifidobacterium lactis W51 i Lactobacillus salivarius W24,

The Fitmate MED device is equipped with a sensor that enables the measurement of inhaled and exhaled air as well as a mask containing disposable mouthpieces and antibacterial filters. During this meeting, in accordance with the simple draw product A (group G1) was given to every second person, and product B (group G2) for the remaining persons. The food diary includes hours of meals, the weight of products and dishes, and the amount of fluids consumed during the day. At the endpoint, FSH level has increased significantly concerning the baseline after the probiotic intake (31.91 vs. 42.00 mIU/ml; p < 0.009). Also, in the placebo group, a strong trend to elevate FSH was observed (22.31 vs. 41.99 mIU/ml; p = 0.055). Body mass has crucially decreased in reference to the baseline in both groups (PRO: 27.90 vs. 26.30 kg/m2, p<0.001; PBO: 25.90 to 24.60 kg/m2, p<0.001).The study consisted of two stages (W1 and W2), and each stage was associated with three visits by the participants. The study took place in the spring (March-June 2018) and autumn (September-December 2018), i.e. during of the most intense period in terms of participation in runners' competitions. Probiotics, defined as "live microorganisms, that when administered in adequate amounts, confer a health benefit on the host", may have the potential to modulate the gut bacterial composition.

Participants will be asked to collect stool samples after overnight fasting to avoid the effect of food consumption on short-chain fatty acid synthesis. Each participant will receive detailed instructions describing the method for material collection. A plastic holder will be used to collect faeces into a sterilized screw-capped collection container. Participants will be asked to store the sample in a fridge and deliver the sample up to 24h after collection to the clinic. The samples will be preserved in 2mL Eppendorf tubes containing 600μL DNA/RNA later solution (Zymo Research, Freiburg, Germany) to prevent the degradation processes and will be frozen at −80°C until the beginning of the microbiota analyses. Probiotics, defined as "live microorganisms, that when administered in adequate amounts, confer a health benefit on the host", may have the potential to modulate the gut bacterial composition. This is why the investigators hypothesize that it may also reduce the intensity of adverse effects associated with metformin use.The body composition analyzer, using the electrical bioimpedance principle, uses low current flow using 6 frequencies and subsequent measurement of the resistance of individual tissues to determine body composition. World Health Organization Obesity, and Overweight. [(accessed on 26 January 2016)]; Available online: http://www.who.int/mediacentre/factsheets/fs311/en/ Forslund K, Hildebrand F, Nielsen T, Falony G, Le Chatelier E, Sunagawa S, Prifti E, Vieira-Silva S, Gudmundsdottir V, Pedersen HK, Arumugam M, Kristiansen K, Voigt AY, Vestergaard H, Hercog R, Costea PI, Kultima JR, Li J, Jorgensen T, Levenez F, Dore J; MetaHIT consortium, Nielsen HB, Brunak S, Raes J, Hansen T, Wang J, Ehrlich SD, Bork P, Pedersen O. Disentangling type 2 diabetes and metformin treatment signatures in the human gut microbiota. Nature. 2015 Dec 10;528(7581):262-266. doi: 10.1038/nature15766. Epub 2015 Dec 2. Erratum In: Nature. 2017 May 3;545(7652):116. The product gluten-free, free of preservatives. Food supplements should not be used as a substitute for a varied diet and a healthy lifestyle. Keep out of reach of children, at room temperature, no need to refrigerate.

kapsułka zawiera łącznie 2,5×10 9 CFU/g bakterii Bifidobacterium lactis W51, Lactobacillus brevis W63, Lactobacillus acidophilus W22, Bifidobacterium bifidum W23 i Lactococcus lactis W58; To monitor cardiac contractions, a Garmin sporttester model HRM-Tri 010-10997-09 (United States) was used.kapsułka zawiera łącznie 3×10 9 CFU/g Lactobacillus helveticus Rosell® – 52 i Bifidobacterium longum Rosell® – 175; You may also open the capsule and sprinkle the probiotic into a cold drink or cold soft food, following the same directions for the oral powder. Cheng J, Ouwehand AC. Gastroesophageal Reflux Disease and Probiotics: A Systematic Review. Nutrients. 2020 Jan 2;12(1):132. doi: 10.3390/nu12010132.